Isocarboxazid

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Isocarboxazid
Systematic (IUPAC) name
N'-benzyl-5-methyl-oxazole-3-carbohydrazide
Identifiers
CAS number	59-63-2
ATC code	N06AF01
PubChem	3759
DrugBank	APRD00701
Chemical data
Formula	C₁₂H₁₃N₃O₂
Mol. mass	231.26
Pharmacokinetic data
Bioavailability	?
Metabolism	Liver
Half life	?
Excretion	Urine
Therapeutic considerations
Pregnancy cat.	C (USA)
Legal status	℞ Prescription only
Routes	Oral

Isocarboxazid is a nonselective hydrazine-derived monoamine oxidase inhibitor used in treatment resistant depression.

1 Uses
- 1.1 Approved
- 1.2 Off-Label/Unapproved/Investigational
2 Brand Names
- 2.1 United States
- 2.2 United Kingdom
3 References

[edit] Uses

[edit] Approved

In the United States, isocarboxazid is approved for the treatment of depression.

In the United Kingdom, isocarboxazid is licensed for the treatment of depression unresponsive to selective serotonin reuptake inhibitors (SSRIs).

[edit] Off-Label/Unapproved/Investigational

A randomized controlled trial published in December of 1988 found that isocarboxazid significantly reduced bingeing and purging in bulimia nervosa, regardless of the presence or absence of depression or personality disorder.^[1]

[edit] Brand Names

[edit] United States

MARPLAN® by Hoffmann-La Roche, starting in 1959 and discontinuing in 1994. After much patient and physician outcry, they resumed manufacturing just enough Marplan® to distribute on an as-needed basis. In October of 1998, Hoffmann-La Roche and Oxford Pharmaceutical Services Inc. announced that Oxford, "is acquiring ownership of the NDA for the antidepressant product Marplan® (isocarboxazid) from Roche."^[2]

The maximum daily dose of isocarboxazid is 60mg.

[edit] United Kingdom

Isocarboxazid is availably generically in the United Kingdom in the form of 10mg tablets. However, it is considered 'less suitable for prescribing' by the British National Formulary (BNF).

[edit] References

drugs.com Isocarboxazid Drug Information
Monoamine-oxidase inhibitors (Group PIM G025) IPCS INTOX Databank
PubChem Substance Summary: Isocarboxazid National Center for Biotechnology Information.

↑ Kennedy SH, Piran N, Warsh JJ, Prendergast P, Mainprize E, Whynot C, Garfinkel PE. "A trial of isocarboxazid in the treatment of bulimia nervosa." Journal of Clinical Psychopharmacology. 1988 Dec;8(6):391-6. PMID 3069879
↑ Marplan Press Release Oxford Pharmaceutical Services.

v • d • e Antidepressants (ATC N06A)
Monoamine oxidase inhibitors (MAOI)	Harmaline, Iproniazid, Isocarboxazid, Nialamide, Pargyline, Phenelzine, Selegiline, Toloxatone, Tranylcypromine RIMAs: Brofaromine, Moclobemide
Dopamine reuptake inhibitor (DARI)	Amineptine, Phenmetrazine, Vanoxerine
Norepinephrine-dopamine reuptake inhibitors (NDRI)	Bupropion
Norepinephrine reuptake inhibitor (NRI) or (NARI)	Atomoxetine, Maprotiline, Reboxetine, Viloxazine
Serotonin-norepinephrine reuptake inhibitor (SNRI)	Duloxetine, Milnacipran, Nefazodone , Venlafaxine
Selective serotonin reuptake inhibitor (SSRI)	Alaproclate, Citalopram, Escitalopram, Etoperidone, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine
Selective serotonin reuptake enhancer (SSRE)	Tianeptine
Noradrenergic and specific serotonergic antidepressant (NaSSA)	Mirtazapine
Tricyclic antidepressants (TCA)	Amitriptyline, Amoxapine, Butriptyline, Clomipramine, Desipramine, Dibenzepin, Dothiepin, Doxepin, Imipramine, Iprindole, Lofepramine, Melitracen, Nortriptyline, Opipramol, Protriptyline, Trimipramine
Tetracyclic antidepressants	Maprotiline, Mianserin, Nefazodone, Trazodone