Isradipine
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Isradipine
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| Systematic (IUPAC) name | |
| methyl propan-2-yl 2,6-dimethyl-4- (8-oxa-7,9-diazabicyclo[4.3.0] nona- 2,4,6,9- tetraen- 5-yl)- 1,4-dihydropyridine- 3,5-dicarboxylate | |
| Identifiers | |
| CAS number | |
| ATC code | C08 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C19H21N3O5 |
| Mol. mass | 371.387 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 95% |
| Metabolism | ? |
| Half life | 8 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Isradipine is a calcium channel blocker of the dihydropyridine class.
[edit] Further reading
- Hattori T, Wang P (2006). "Calcium antagonist isradipine-induced calcium influx through nonselective cation channels in human gingival fibroblasts.". Eur J Med Res 11 (3): 93-6. PMID 16751108.
- Ganz M, Mokabberi R, Sica D (2005). "Comparison of blood pressure control with amlodipine and controlled-release isradipine: an open-label, drug substitution study.". J Clin Hypertens (Greenwich) 7 (4 Suppl 1): 27-31. PMID 15858400.
- Johnson B, Roache J, Ait-Daoud N, Wallace C, Wells L, Dawes M, Wang Y (2005). "Effects of isradipine, a dihydropyridine-class calcium-channel antagonist, on d-methamphetamine's subjective and reinforcing effects.". Int J Neuropsychopharmacol 8 (2): 203-13. PMID 15850499.
- Fletcher H, Roberts G, Mullings A, Forrester T (1999). "An open trial comparing isradipine with hydralazine and methyl dopa in the treatment of patients with severe pre-eclampsia.". J Obstet Gynaecol 19 (3): 235-8. PMID 15512286.
[edit] External links
| Calcium channel blockers (C08) | |
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| Dihydropyridines | Amlodipine, Felodipine, Isradipine, Lacidipine, Lercanidipine, Nicardipine, Nifedipine, Nimodipine, Nisoldipine |
| Phenylalkylamines | Verapamil |
| Benzothiazepines | Diltiazem |
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