Jamaican vomiting sickness
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Jamaican vomiting sickness is an acute vomiting and hypoglycemic disease caused by the consumption of the toxin hypoglycin in unripened fruit of the Ackee tree. In the human body, hypoglycin is metabolised to produce methylenecyclopropylacetyl-CoA (MCPA-CoA). MCPA-CoA irreversibly inhibits short- and medium-chain acyl-CoA dehydrogenases. Hypoglycemia results when glucose becomes the primary energy source, as opposed to fatty acids. In more serious cases, patients have convulsions and enter metabolic comas.
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