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General José Santos Guardiola (November 1, 1816 – January 11, 1862) was President of Honduras from February 17, 1856 to January 11, 1862, when he became the only President of Honduras to be assassinated while in office in a crime committed by his personal guard. He was born in 1816 in Tegucigalpa, Honduras. He opposed Francisco Morazán in the conflict over whether to have a Central American state. His good relations with the British helped facilitate the incorporation of the Bay Islands and the La Mosquitia region into Honduras. He fought against William Walker, who aspired to conquering Central America.
