Ki-67 (Biology)
From Wikipedia, the free encyclopedia
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PROLIFERATION-RELATED Ki-67 ANTIGEN
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| Identifiers | |
| Symbol | MKI67 Ki-67; KIA |
| HUGO | [1] |
| Entrez | 4288 |
| OMIM | 176741 |
| UniProt | P46013 |
| Other data | |
| Locus | Chr. 10 q25 |
The Ki-67 protein is a cellular marker for proliferation. It is strictly associated with cell proliferation. During the interphase, the Ki-67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. Ki-67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells (G0). Ki-67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of Ki-67-positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. The best-studied examples in this context are carcinomas of the prostate and the breast. For these types of tumors, the prognostic value for survival and tumor recurrence have repeatedly been proven in uni- and multivariate analysis.
The Ki-67 protein was originally defined by the prototype monoclonal antibody Ki-67 [1], which was generated by immunizing mice with nuclei of the Hodgkin lymphoma cell line L428. The name is derived from the city of origin (Kiel) and the number of the original clone in the 96-well plate.
[edit] References
- ^ Gerdes J, Schwab U, Lemke H, Stein H. 1983. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31:13–20.
[edit] Literature
Scholzen and Gerdes; The Ki-67 Protein: From the Known and the Unknown; Journal of Cellular Physiology 182:311–322 (2000); Review
