Talk:Kupffer cell
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Page moved moved from Kuppfer cell to Kupffer cell (named for Karl Wilhelm von Kupffer). Rd232 21:48, 16 October 2005 (UTC)
Note:
Kupffer cells are thought to express little MHC class II and no TLR-4 (Toll like receptor). This is because they are resident in the liver and their job is to remove the large numbers of dying cells from the blood. This means they are taking up a lot of self antigens. Hence, it is vital for them to not be easily activated (to express co-stimmulatory signals e.g. through TLR-4) because otherwise they could easily cause an autoimmune response.
-> I don't have time to put it in.... can someone else phrase it better and do it? The information is up to date and correct. thx
TLR4 is expressed on Kupffer cells.
See Tsung et al 'Hepatic Ischemia/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells' Journal of Immunology (2005) 175: 7661–7668.
