Laura Manuelidis

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Laura Manuelidis is a physician and neuropathologist at Yale University. She earned her B.A. degree from Sarah Lawrence College, where she studied poetry, and her M.D. from Yale Medical School. She is head of head of the section of Neuropathology in the department of Surgery at Yale. She is also also on the faculty of Neurosciences and Virology. Her work centers around elucidating the mechanisms of infection in Transmissible spongiform encephalopathy (TSEs).^[1]

She has challenged the conventionally accepted explanation for the cause of Bovine spongiform encephalopathy (better known as "Mad Cow Disease") and the human equivalent, Creutzfeldt-Jakob disease. The generally accepted explanation was put forth by Stanley B. Prusiner who won the 1997 Nobel Prize in physiology or medicine.^[2] In his work, he coined the term prion (a portmanteau for "proteinacious infectious agents") to refer to a previously undescribed form of infection due to malformed proteins.^[3] In January 2007 Menuelidis and her colleagues published an article in the Proceedings of the National Academy of Science asserting that they found a virus that could be responsible for the diseasees. Manulidis said, “Although much work remains to be done, there is a reasonable possibility these are the long sought viral particles that cause transmissible spongiform encephalopathies, The [prion] is probably not infectious, but is a pathological result [of] an infectious virus binding to this host protein.”^[4]