Talk:Lefetamine
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[edit] Prototype for modern anorexics
More recently, lefetamine has served as a prototype for some more modern anorexics. A good example of this is 'The synthesis of pyrrole analogues of the analgesic drug lefetamine is reported. These derivatives bear the 1-phenyl-2-(1H-pyrrol-1-yl)ethylamino moiety. Compounds were evaluated for analgesic activities in mice by the hot plate and Randall-Selitto tests. Antiinflammatory activity was tested by the carrageenan-induced rat paw edema method. General neuropsychopharmacological effects were also screened. The most interesting compound, N,N-dimethyl-1-phenyl-2-(1H-pyrrol-1-yl)ethylamine, showed an analgesic effect comparable to that of lefetamine, but devoid of the neurotoxicity of this drug.'*
- Synthesis, neuropsychopharmacological effects and analgesic-antiinflammatory activities of pyrrole analogues of lefetamine.
Massa S, Stefancich G, Artico M, Corelli F, Silvestri R, Pantaleoni GC, Fanini D, Palumbo G, Giorgi R.
Dipartimento di Studi Farmaceutici, Facolta di Farmacia, Universita degli Studi di Roma La Sapienza, Italy.
Interesting, n'est pas.—The preceding unsigned comment was added by 81.104.26.110 (talk • contribs).
