LHRH receptor
From Wikipedia, the free encyclopedia
gonadotropin-releasing hormone receptor
|
|
Identifiers | |
Symbol | GNRHR GRHR |
HUGO | 4421 |
Entrez | 2798 |
OMIM | 138850 |
RefSeq | NM_001012763 |
UniProt | P30968 |
Other data | |
Locus | Chr. 4 q21.2 |
The luteinizing hormone releasing hormone receptor is 60 kDa G protein-coupled receptor resides primarily in the pituitary and is responsible for eliciting the actions of LHRH after its release from the hypothalamus. Upon activation, the LHRHr stimulates tyrosine phosphatase and elicits the release of LH from the pituitary.
Evidence exists showing the presence of LHRH and its receptor in extrapituitary tissues as well as a role in progression of some cancers.
CRH - FSH - LHRH - TRH - Somatostatin
Vasopressin (1A, 1B, 2) - Oxytocin - LHCG - GH - Prolactin - TSH
Angiotensin - Atrial natriuretic factor - Bradykinin - Calcitonin - Calcitonin gene-related peptide - Cholecystokinin - Galanin - Neuropeptide Y - Neurotensin - Opioid (Delta, Kappa, Mu, Sigma, Nociceptin) - Tachykinin - VIP