Machine perfusion
From Wikipedia, the free encyclopedia
Machine perfusion (MP) is a technique used in organ transplantation as a means of preserving the organs which are to be transplanted. So far it has mainly been used in kidney transplantation. It is an alternative to cold storage (CS). Its clinical and cost-effectiveness are still subject to research.[1]
Hypothermic perfusion has given the longest storage time for canine kidneys with the best result being 8 day storage.[2] This experimental model used a storage temperature of 8°C and a Plasma Protein Fraction (PPF) based perfusate.[3] The octanoic acid content of PPF was found to influence the results of preservation in 5 day storage.[4] Both Octanoic acid and Oleic acid stimulated oxygen consumption to a similar degree during hypothermic perfusion[5]suggesting that the detrimental effect of Octanoic acid was due to direct metabolic stimulation rather than uncoupling of oxidatative phosphorylation.[6]
[edit] References
1. Wight J, Chilcott J, Holmes M, Brewer N (2003). "The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors". Health Technol Assess 7 (25): 1-94. PMID 14499050.
2. Cohen GL. 8 day kidney preservation. Liverpool University, 1982. Ch.M. Thesis.
3. Cohen GL, Johnson RWG. Perfusate buffering for 8-day canine kidney storage. Proceedings of the European Society for Artificial Organs 1980;7:235-239.
4. Cohen GL, Hunt L, Johnson RWG. Octanoate toxicity in 5 day kidney preservation. Cryobiology 1983;20:731.
5. Cohen GL, Burdett K, Johnson RWG. Stimulation of oxygen consumption by oleic and octanoic acid during hypothermic kidney preservation. Cryobiology 1985;22:615-616.
6. Cohen GL, Burdett K, Hunt L, Johnson RWG. Uncoupling of oxidative phosphorylation by octanoic acid during 5-day hypothermic kidney preservation. Cryobiology 1984;21:699-700.
Types of Transplants: Allograft - Alloplant - Allotransplantation - Autotransplantation - Xenotransplantation
Tissue and Organs Transplanted: Organ transplant - Bone grafting - Bone marrow - Corneal - Face - Hand - Heart - Heart-Lung - Kidney - Liver - Lung - Pancreas - Penis - Skin grafting - Spleen - Uterus
Related issues: Cellular memory - Biomedical tissue - Edmonton protocol - Eye bank - Graft-versus-host disease - Immunosuppressive drugs - Islet cell transplantation - Living donor liver transplantation - Lung allocation score - Machine perfusion - Medical grafting - Non-heart beating donation - Organ donation - Post-transplant lymphoproliferative disorder - Total body irradiation - Transplant rejection
Organizations related to Transplants: Human Tissue Authority - National Marrow Donor Program - United Network for Organ Sharing
People related to transplants: Christiaan Barnard - Isabelle Dinoire - Jean-Michel Dubernard - Gregory Scott Johnson - List of notable organ transplant donors and recipients
 |
This medical article is a stub. You can help Wikipedia by expanding it. |
