Mitragynine
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| Mitragynine | |
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| Systematic name | Mitragynine |
| Chemical formula | C23H30N2O4 |
| Molecular mass | 398.2206 g/mol |
| Density | x.xxx g/cm³ |
| Melting point | 39 - 41 °C |
| Melting point of HCl Salt | 117.22 °C |
| Boiling point | 110 - 115.6 °C |
| CAS number | [4098-40-2] |
| SMILES | xxxxx |
| Disclaimer and references | |
Mitragynine, an indole, is the primary active alkaloid in the plant mitragyna speciosa, commonly known as Kratom. On small doses its activity is reported to be stimulant like, while in higher doses more opiate like. Its potential for treating drug addiction, perhaps in combination with ibogaine, is being investigated.
Mitragynine was isolated in 1907 by D. Hooper, a process repeated in 1921 by E. Field who gave the alkaloid its name. Its structure was first fully determined in 1964 by D. Zacharias, R. Rosenstein and E. Jeffrey.
It is structurally related to both the yohimbe alkaloids and voacangine. It is more distantly related to other tryptamine-based psychedelic drugs such as psilocybin or LSD. Chemically, mitragynine is 9-methoxy-corynantheidine. Mitragynine acts as a fairly selective δ-opioid agonist with little affinity for μ or κ receptors.
[edit] Chemical traits
Physically the freebase is a white, amorphous powder. It is soluble in alcohol, chloroform and acetic acid.
[edit] References
- Takayama H.; Maeda M.; Ohbayashi S.; Kitajima M.; Sakai S.-i.; Aimi N. (1995). "The First Total Synthesis of (-)-Mitragynine, An Analgesic Indole Alkaloid in Mitragyna speciosa". Tetrahedron Letters 36 (51): 9337-9340. DOI:10.1016/0040-4039(95)02022-H.
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