Negative regulation

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Negative Regulation is a mechanism for regulating facultative genes. It is most common in prokaryotes. Embedded in the promoter is a cis-acting site called an operator. The complementary structure found on the regulatory enzyme is called the repressor. When these two bind to each other they block the binding of RNA polymerase so that transcription is prevented.

[edit] References

Merrill, Dr. Gary F. 'Transcription', lecture notes distributed in Biochemistry 451 General Biochemistry, Oregon State University, Weigend on 06 June 2006.