Neural facilitation
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In Neuroscience, Neural Facilitation, also known as Paired Pulse Facilitation is the increase in postsynaptic potential (EPP, EPSP) evoked by a 2nd impulse.
The phenomena of paired-pulse facilitation (PPF) and depression (PPD) are well known short-term forms of synaptic plasticity. They are expressed in electrophysiological experiments as changes in the amplitude of a test EPSC evoked by a second presynaptic spike that follows the first (conditioning) one in the paired-pulse paradigm.
The presence of PPF or PPD is dependent on the types of synapses and the experimental conditions. It varies strongly according to the interval between the conditioning and test pulses. Short-term plasticity can be responsible for cognitive abilities involving temporal processes eg. the determination of: order, duration, and interval.
This is an example of a dynamic synapse.
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