Niaprazine

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Niaprazine (Nopron) is a piperazine derivative drug which acts as a sedating antihistamine. It was invented in the 1970s ^[1], and is used in France and other european countries. It is mainly prescribed for its relatively strong sedative effects rather than as an antihistamine, and is used mainly for treating autism ^[2] and insomnia ^[3] in children and adolescents.

Niaprazine half-life is 4.53 +- 0.86 hours.

Common side effects are: sedation during the day (above all during the first few days), vertigo

N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide

CAS# 27367-90-4; 34426-53-4

[edit] References

1. ^ Duchene-Marullaz P, Rispat G, Perriere JP, Hache J, Labrid C. Some pharmacodynamical properties of niaprazine, a new antihistaminic agent. (French) Therapie. 1971 Nov-Dec;26(6):1203-9.
2. ^ Rossi PG, Posar A, Parmeggiani A, Pipitone E, D'Agata M. Niaprazine in the treatment of autistic disorder. Journal of Child Neurology. 1999 Aug;14(8):547-50.
3. ^ Younus M, Labellarte MJ. Insomnia in children: when are hypnotics indicated? Paediatric Drugs. 2002;4(6):391-403.

v • d • e Antihistamines (primarily R06)
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Substituted ethylene diamines	Chloropyramine, Histapyrrodine, Mepyramine, Methapyrilene, Pyribenzamine
Phenothiazine derivatives	Alimemazine, Hydroxyethylpromethazine, Isothipendyl, Mequitazine, Methdilazine, Oxomemazine, Promethazine
Piperazine derivatives	Buclizine, Cetirizine, Chlorcyclizine, Cinnarizine, Cyclizine, Hydroxyzine, Levocetirizine, Meclozine, Niaprazine, Oxatomide
Others for systemic use	Acrivastine, Antazoline, Astemizole, Azatadine, Azelastine, Bamipine, Cyproheptadine, Deptropine, Desloratadine, Ebastine, Epinastine, Ketotifen, Loratadine, Mebhydrolin, Mizolastine, Phenindamine, Pimethixene, Pyrrobutamine, Rupatadine, Terfenadine, Triprolidine
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Antiallergic agents excluding corticosteroids	Antazoline, Azelastine, Fexofenadine
Other antiallergics	Emedastine, Epinastine, Ketotifen, Olopatadine