Norepinephrine transporter

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solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Identifiers
Symbol	SLC6A2 NET1, NAT1, SLC6A5
HUGO	11048
Entrez	6530
OMIM	163970
RefSeq	NM_001043
UniProt	P23975
Other data
Locus	Chr. 16 q12.2

The noradrenaline transporter or NAT is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree.

Certain antidepressant medications act to raise noradrenaline, such as the SNRIs and the tricyclic antidepressants (TCAs). In other words, these medications prevent the noradrenaline transporter from doing its job. Noradrenaline therefore remains in the synapse longer, allowing it to reach more normal levels. Since the noradrenaline transporter is also thought to transport dopamine to some extent, SNRIs would also raise dopamine levels in the synapse.

A loss of function mutation in the noradrenaline transporter has been associated with postural orthostatic tachycardia syndrome in one kindred.^[1] An epigenetic mechanism (hypermethylation of CpG islands in the NET gene promoter region^[2]) that results in reduced expression of the noradrenaline transporter and consequently a phenotype of impaired neuronal reuptake of noradrenaline has been implicated in both postural orthostatic tachycardia syndrome and panic disorder.

[edit] See also

Neurotransmitter transporter

[edit] References

^ Shannon J, Flattem N, Jordan J, Jacob G, Black B, Biaggioni I, Blakely R, Robertson D (2000). "Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency". N Engl J Med 342 (8): 541-9. PMID 10684912.
^ Esler M, Alvarenga M, Pier C, Richards J, El-Osta A, Barton D, Haikerwal D, Kaye D, Schlaich M, Guo L, Jennings G, Socratous F, Lambert G (2006). "The neuronal noradrenaline transporter, anxiety and cardiovascular disease". J Psychopharmacol 20 (4 Suppl): 60-6. PMID 16785272.