Normoblast

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An erythroblast is a type of red blood cell which still retains a cell nucleus. It is the immediate precursor of a normal erythrocyte.

Contents 1 Nomenclature 2 Development 3 Additional images 4 See also 5 External links

[edit] Nomenclature

The term normoblast is sometimes used as a synonym for erythroblast, but at other times it is considered a subcategory. In the latter context, there are two types of erythroblasts:

• "normoblasts" - develop as expected
• "megaloblasts" - an unusually large erythroblast that can be associated with pernicious anemia and folic acid deficiency (collectively called megaloblastic anemia)

[edit] Development

There are four stages in the development of a normoblast.

Image	Description
	Pronormoblast
	Basophilic normoblast
	Polychromatic normoblast (also polychromatophilic)
	Orthochromatic normoblast (also orthochromatophilic)

[edit] Additional images

Blood cell lineage

Hematopoiesis

[edit] See also

• Erythropoiesis
• Hemopoiesis
• Pluripotential hemopoietic stem cell

[edit] External links

• Dorlands/Elsevier n_10/12578105 - "normoblast"
• Dorlands/Elsevier e_15/12341680 - "erythroblast"
• Dictionary at eMedicine normoblast
• MeSH Normoblasts
• Histology at BU 01804loa - "Bone Marrow and Hemopoiesis bone marrow smear, erythroblast series with proerythroblast "
• Histology at uiowa.edu

v • d • e Blood
Plasma	Hematopoietic stem cells - Red blood cells (Reticulocyte, Normoblast) - White blood cells
Lymphoid	T cells: Cytotoxic CD8+, Helper CD4+/Regulatory, γδ, Natural Killer T cell B cells: Plasma, Memory Natural killer cells
Myeloid	Granulocytes (Neutrophil, Eosinophil, Basophil) - Mast cell precursors Dendritic cells (Langerhans cells) - Monocytes/Macrophages (Histiocytes, Kupffer cells, Langhans giant cells, Microglia, Osteoclasts) Megakaryoblast - Megakaryocyte - Platelets