Olmesartan
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Olmesartan
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| Systematic (IUPAC) name | |
| ? | |
| Identifiers | |
| CAS number | |
| ATC code | C09 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C29H30N6O6 |
| Mol. mass | 558.585 g/mol |
| Pharmacokinetic data | |
| Bioavailability | Rapid and complete absorption |
| Metabolism | Hepatic (cannot be removed by hemodialysis) |
| Half life | 13 hours |
| Excretion | Primarily fecal, small amount in urine |
| Therapeutic considerations | |
| Pregnancy cat. |
C (D if used in second or third trimester) |
| Legal status |
℞ Prescription only |
| Routes | Oral |
Olmesartan (Benicar®) belongs to the class of medicines called angiotensin II receptor antagonists to treat high blood pressure. It is marketed worldwide by Daiichi Sankyo, Ltd. and in the United States by Daiichi Sankyo, Inc, and Forest Laboratories. Olmesartan works by blocking the action of angiotension II. As a result of this blockage, olmesartan restricts vasoconstriction and the secretion of aldosterone. This lowers blood pressure by producing vasodilation, and decreasing peripheral resistance.
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[edit] Administration
Olmesartan is available in 5, 20, and 40 mg tablets. A normal dose for an adult (including the elderly and mild renal or hepatic impairment) is 20 mg/day in one dosage. This may be increased after two weeks to 40 mg/day if further blood pressure reduction is needed.
[edit] Side effects
Side effects include:
- Dizziness
- Headache
- Diarrhea
- Upper respiratory tract infection
- Reduced libido
[edit] References
Hodgson, Barbara B., and Kizior, Robert J. Saunders Nursing Drug Handbook 2006. St. Louis, MO: Elsevier, Saunders, 2006.
[edit] External links
Candesartan, Eprosartan, Irbesartan, Losartan, Olmesartan, Tasosartan, Telmisartan, Valsartan
