Parkinsonism
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| DiseasesDB | 24212 |
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| MedlinePlus | 000759 |
Parkinsonism describes the common motor symptoms of Parkinson's disease: tremor, rigidity, akinesia or bradykinesia and postural instability.
The differential diagnosis or list of potential causes for this disease includes:
- Corticobasal degeneration
- Creutzfeldt-Jakob disease
- Diffuse Lewy body disease
- Drug-induced parkinsonism (e.g. antipsychotics, metoclopramide)
- Encephalitis lethargica
- Hallervorden-Spatz syndrome
- HIV/AIDS can sometimes lead to symptoms of Parkinson's disease. Subclinical nigral degeneration is common in AIDS and would explain the heightened susceptibility to parkinsonism, as this would lead to dopaminergic dysfuntion.
- Multiple system atrophy
- Progressive supranuclear palsy
- Toxicity (due to substances such as manganese and MPTP)
- Vascular Parkinsonism
- Wilson's disease. Wilson's disease is a genetic disorder in which there is an abnorma accumulation of copper. The excess copper that occurs in Wilson's disease can cause the formation of a copper-dopamine complex, which leads to the oxidation of dopamine to aminochrome.
Bold text==Reference==
- Anthony E. Lang, M.D. & Andres M. Lozano, M.D. (October 15, 1998) "Parkinson's Disease - Second of Two Parts", New England Journal of Medicine 339:1130 - 1143. Number 16.
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