Polyglycylation

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This is a form of post translational modification of glutamate residues of the carboxyl-terminal region tubulin in certain microtubules (eg axonemal) originally discovered in paramecium^[1], and later shown in mammalian neurons as well^[2].

[edit] References

1. ^ Redeker, V., Levilliers, N., Schmitter, J.M., Le Caer, J.P., Rossier, J., Adoutte, A., and Bré, M.H. (1994). Polyglycylation of tubulin: a posttranslational modification in axonemal microtubules. Science 266, 1688-1691 ( http://www.sciencemag.org/cgi/content/abstract/266/5191/1688 )
2. ^ Asok Banerjee Coordination of Posttranslational Modifications of Bovine Brain alpha -Tubulin. POLYGLYCYLATION OF Delta 2 TUBULIN J. Biol. Chem. 277: 46140-46144 ( http://www.jbc.org/cgi/content/full/277/48/46140 )

Protein primary structure and posttranslational modifications
General:	Protein biosynthesis | Peptide bond | Proteolysis | Racemization | N-O acyl shift
N-terminus:	Acetylation | Formylation | Myristoylation | Pyroglutamate | methylation | glycation | myristoylation (Gly) | carbamylation
C-terminus:	Amidation | Glycosyl phosphatidylinositol (GPI) | O-methylation | glypiation | ubiquitination | sumoylation
Lysine:	Methylation | Acetylation | Acylation | Hydroxylation | Ubiquitination | SUMOylation | Desmosine | deamination and oxidation to aldehyde| O-glycosylation | imine formation | glycation | carbamylation
Cysteine:	Disulfide bond | Prenylation | Palmitoylation
Serine/Threonine:	Phosphorylation | Glycosylation
Tyrosine:	Phosphorylation | Sulfation | porphyrin ring linkage | flavin linkage | GFP prosthetic group (Thr-Tyr-Gly sequence) formation | Lysine tyrosine quinone (LTQ) formation | Topaquinone (TPQ) formation
Asparagine:	Deamidation | Glycosylation
Aspartate:	Succinimide formation
Glutamine:	Transglutamination
Glutamate:	Carboxylation | polyglutamylation | polyglycylation
Arginine:	Citrullination | Methylation
Proline:	Hydroxylation
←Amino acids		Secondary structure→