Talk:Psoralen
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'Tis also used in treating leukemia and T-cell cancers. UV is also the main component in so-called Rife therapy...usually 3 different wavelengths at once.--sascha r.
- Do you have any books or refs on that? I'm a chemist, so I know little about that stuff. Thanks, Walkerma 06:16, 16 March 2006 (UTC)
[edit] Psoralen is also an "Intercalating Agent".
There is no mention of the possible negative side effects Psoralen has.
Psoralen intercalates into the DNA and, on exposure to ultraviolet (UVA) radiation, can form covalent ICLs with thymines preferentially at 5'-TpA sites in the genome, inducing apoptosis. Psoralen plus UVA (PUVA) therapy has shown considerable clinical efficacy1. Unfortunately, a side effect of PUVA treatment is a higher risk of skin cancer2.
1. Qi Wu, Laura A Christensen, Randy J Legerski & Karen M Vasquez (2005) Mismatch repair participates in error-free processing of DNA interstrand crosslinks in human cells. Full Article
2. Momtaz K, Fitzpatrick TB (1998) The benefits and risks of long-term PUVA photochemotherapy. Dermatol Clin 16: 227−234 PubMed —The preceding unsigned comment was added by 85.250.37.217 (talk) 11:09, 12 March 2007 (UTC).
