Resolvins
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Resolvins are compounds that are made by the human body from the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). They are produced by the COX-2 pathway especially in the presence of aspirin. Experimental evidence indicates that resolvins reduce cellular inflammation by inhibiting the production and transportation of inflammatory cells and chemicals to the sites of inflammation. They are released and used immunologically by the kidneys as a tool against acute renal failure, when it occurs.
Resolvins are sometimes classed with the eicosanoids.
[edit] External links
- Charles N. Serhan et al, "Resolvins: A Family of Bioactive Products of Omega-3 Fatty Acid Transformation Circuits Initiated by Aspirin Treatment that Counter Proinflammation Signals" [1], The Journal of Experimental Medicine, Volume 196, Number 8, 1025-1037. URL reference on 10/24/05.
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