Separase
From Wikipedia, the free encyclopedia
Separase is a cysteine protease (EC 3.4.22.49) responsible for triggering anaphase by hydrolysing cohesin which is the protein responsible for binding sister chromatids during metaphase.
When the cell is not dividing, separase is prevented from cleaving cohesin through its association with another protein, securin. On the signal for anaphase, the securin is ubiquitinated and hydrolysed, releasing active separase.
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| Separase | |
|---|---|
| Gene code: | [1] ID#AAB03897.1 |
| Structure: | Unknown |
| Recent publications: | [2]Requirement for ESP1 in the nuclear division of Saccharomyces cerevisiae., [3] An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast., |
| Taxa expressing: | Eukaryotes |
| Cell types: | all |
| Subcellular localization: | Nucleus |
