Sotalol
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Sotalol
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| Systematic (IUPAC) name | |
| N-[4-(1-hydroxy-2-isopropylamino- ethyl)-phenyl]-methanesulfonamide |
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| Identifiers | |
| CAS number | |
| ATC code | C07 |
| PubChem | |
| Chemical data | |
| Formula | C12H20N2O3S |
| Mol. mass | 272.3624 g/mol |
| Pharmacokinetic data | |
| Bioavailability | >95% |
| Metabolism | Not metabolised |
| Half life | 12 hours |
| Excretion | Renal Lactic (In lactiferous females) |
| Therapeutic considerations | |
| Pregnancy cat. |
B(US) |
| Legal status |
℞ Prescription only |
| Routes | oral |
Sotalol (trade names Betapace® and Betapace AF®, Berlex Laboratories) is a drug used in individuals with rhythm disturbances (cardiac arrhythmias) of the heart, and to treat hypertension in some individuals.
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[edit] Pharmacology
It falls into the class III antiarrhythmic agents) because it inhibits the inward potassium ion channels in the heart. It is also a beta blocker because of its primary action on the β-adrenergic receptors in the heart.
By blocking the postassium channels, sotalol prolongs repolarization, therefore lengthening the QT interval and decreasing automaticity.
It also slows atrioventricular (AV) nodal conduction. (Beta-blocking effect).
Sotalol is a racemic mix of D and L enantiomers. The L isomer is a beta blocker.
Sotalol is not selected for is beta-blocking ability, but rather for its Class III (potassium blocking) properties.
[edit] Indications
Sotalol is used to treat ventricular tachycardias as well as atrial fibrillation. Betapace AF is specifically labeled for atrial fibrillation.
Some evidence suggests that sotalol should be avoided in the setting of decreased ejection fraction due to heart attack.[1]
[edit] Footnotes
- ^ Waldo A, Camm A, deRuyter H, Friedman P, MacNeil D, Pauls J, Pitt B, Pratt C, Schwartz P, Veltri E (1996). "Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol.". Lancet 348 (9019): 7-12. PMID 8691967.
[edit] See also
| Beta blockers (C07) | |
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| Non-selective β antagonists (C07AA) | Metipranolol, Nadolol, Oxprenolol, Penbutolol, Pindolol, Propranolol, Timolol, Sotalol |
| β1 antagonists (cardioselective) (C07AB) | Atenolol, Acebutolol, Betaxolol, Bisoprolol, Esmolol, Metoprolol, Nebivolol |
| Mixed α1/β antagonists (C07AG) | Carvedilol, Labetalol |
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