Talk:Tamoxifen

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1 Olof H. Pearson
2 Identified in early 1960s
3 Side Effects
4 Question
5 Ormeloxifene main article needs editors
6 Estrogen = Oestrogen?
7 Other uses of Tamoxifen

[edit] Olof H. Pearson

Olof H.Pearson MD, an endocrinologist and oncologist, did the first research into the use of antiestrogens to treat breast cancer and was the first physician to use steroid hormones to treat lymphomas. He discovered that the hormone prolactin stimulated breast cancer growth and showed that removing the pituitary, the source of the hormone, could lengthen patients' lives. He later helped develop drugs that blocked the hormone without the need for surgery. Today, the antiestrogen tamoxifen routinely is used to treat breast cancer and prevent recurrences after surgery or radiation.

He initially experimented with using cortisone and other adrenal corticosteroid hormones to treat lymphoma and leukemia in the 1940s.

A native of Boston, Pearson earned his medical degree at Harvard Medical School in 1939. He served as flight surgeon and medical director for Pan American World Airways in North America during World War II. He taught at the Harvard and Cornell medical schools and worked at the Sloan-Kettering Institute before joining the faculty of the CWRU School of Medicine and the staff of University Hospitals of Cleveland in 1960. He retired in 1988 and passed away in 1990. 68.51.226.87 (talk • contribs)

Perhaps this should go on Olof Pearson. Is this your own work or copied from elsewhere? JFW | T@lk 12:39, 11 December 2005 (UTC)

[edit] Identified in early 1960s

Note that tamoxifen was identified in the early 1960s as an antiestrogen. The team thought that by inhibiting oestrogen in the uterus, tamoxifen might block pregnancy and act as a "morning after pill". However, later studies showed that instead of preventing pregnancy, it enhanced the chances of pregnancy in subfertile women.

[edit] Side Effects

I haven't got time at the moment as I'm revising for my finals, but this article ought to mention the side effects of Tamoxifen. My oncology lecturer mentioned that whilst the incidence of breast cancer is reduced, other cancers increase in frequency and that overall mortality of breast cancer patients is not significantly improved when using the drug. I haven't had chance to read any related journal articles in detail, but once I have time I will have look. --Shastrix 14:03, 17 March 2006 (UTC)

Excellent idea, now that Raloxifene has been shown to be just as effective, but has fewer side effects. Brian Sayrs 00:48, 18 April 2006 (UTC)

[edit] Question

Is there a proposed mechanism of action for tamoxifen as there is for Gleevec or other targeted therapies?

[edit] Ormeloxifene main article needs editors

I've tried posting in Wikiproject:Clinical medicine, and have found few who know anything about ormeloxifene. Especially needed are chemists, scientists, and doctors who are knowledgable about this SERM. Thank you! -- Joie de Vivre 14:40, 14 December 2006 (UTC)

[edit] Estrogen = Oestrogen?

Are these the same? Using a consistent spelling would make the article clearer. —The preceding unsigned comment was added by 68.190.123.114 (talk) 21:02, 17 December 2006 (UTC).