TGF beta 2
From Wikipedia, the free encyclopedia
| Transforming growth factor beta-2 | |
|---|---|
| Other names: | TGF-beta-2, Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin |
| Genetic data | |
| Locus: | Chr. 1 q41 |
| Gene code: | HUGO code:TGFB2 |
| Protein Structure/Function | |
| Structure: | Molecular structure |
| Protein type: | TGF beta family |
| Other | |
| Taxa expressing: | Homo sapiens; homologs: many metazoan phyla |
| Cell types: | many |
| Subcellular localization: | extracellular |
| Covalent modifications: | glycosylation |
| Database Links | |
| Entrez: | 7042 |
| OMIM: | 190220 |
| RefSeq: | NM_003238 |
| UniProt: | P61812 |
Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development. It is known to suppress the effects of interleukin dependent T-cell tumors. There are two named isoforms of this protein, created by alternative splicing of the same gene.
TGF beta superfamily of ligands:
Activin A and B - Anti-müllerian hormone - Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) - Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF9, GDF10, GDF11, GDF15) - Inhibin A and B - Myostatin - Nodal - TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Type II receptors:ACVR2A - ACVR2B - AMHR2 - BMPR2 - TGFBR2 - TGFBR3
Type I receptors: ACVR1A - ACVR1B - ACVR1C - ACVRL1 - BMPR1A - BMPR1B - TGFBR1
Signal transducers/SMAD: R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors: Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
