Thomas Silhavy

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Thomas J. Silhavy is an American molecular biologist and professor at Princeton University. He has made significant contributions to the field of bacterial genetics such as signal transduction, protein secretion, bacterial stress responses, and outer membrane biogenesis.

Silhavy was elected to the National Academy of Sciences in 2005.

Selected Publications

Button JE, Silhavy TJ, Ruiz N (2006). A suppressor of cell death caused by the loss of {sigma}E downregulates extracytoplasmic stress responses and outer membrane vesicle production in Escherichia coli. J Bacteriol. [Epub ahead of print]

Ruiz N, Wu T, Kahne D, Silhavy TJ (2006). Probing the barrier function of the outer membrane with chemical conditionality. ACS Chem Biol 1: 385-395.

Ureta AR, Endres RG, Wingreen NS, Silhavy TJ (2006). Kinetic analysis of the assembly of the outer membrane protein LamB in Escherichia coli mutants each lacking a secretion or targeting factor in a different cellular compartment. J Bacteriol 189: 446-454.

Gaal T, Mandel MJ, Silhavy TJ, Gourse RL (2006). Crl facilitates RNA polymerase holoenzyme formation. J Bacteriol 188: 7966-7970.

Malinverni JC, Werner J, Kim S, Sklar JG, Kahne D, Misra R, Silhavy TJ (2006). YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli. Mol Microbiol 61: 151-164.

Peterson CN, Carabetta VJ, Chowdhury T, Silhavy TJ (2006). LrhA regulates rpoS translation in response to the Rcs phosphorelay system in Escherichia coli. J Bacteriol 188: 3175-3181.

Ruiz N, Kahne D, Silhavy TJ (2006). Advances in understanding bacterial outer-membrane biogenesis. Nat Rev Microbiol 4: 57-66.

Isaac DD, Pinkner JS, Hultgren SJ, Silhavy TJ (2006). The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP. Proc Natl Acad Sci USA 102: 17775-17779.

Justice SS, Hunstad DA, Harper JR, Duguay AR, Pinkner JS, Bann J, Frieden C, Silhavy TJ, Hultgren SJ (2005). Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli. J Bacteriol 187: 7680-7686.

Peterson CN, Mandel MJ, Silhavy TJ (2005). Escherichia coli starvation diets: essential nutrients weigh in distinctly. J Bacteriol 187: 7549-7553.

Ruiz N, Falcone B, Kahne D and Silhavy TJ (2005). Chemical conditionality: a genetic strategy to probe organelle assembly. Cell 121: 307-317.

Wu T, Malinverni J, Ruiz N, Kim S, Silhavy TJ and Kahne D (2005). Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli. Cell 121: 235-245.

Ruiz N, Silhavy TJ (2005). Sensing external stress: watchdogs of the Escherichia coli cell envelope. Curr Opin Microbiol 8: 122-126.

Mandel MJ and Silhavy TJ (2005). Starvation for different nutrients in Escherichia coli results in differential modulation of RpoS levels and stability. J Bacteriol 187: 434-442.

Duguay AR, Silhavy TJ (2004). Quality control in the bacterial periplasm. Biochim Biophys Acta 1694: 121-134.

Batchelor E, Silhavy TJ, Goulian M (2004). Continuous control in bacterial regulatory circuits. J Bacteriol 186: 7618-7625.

Peterson CN, Ruiz N and Silhavy TJ (2004). RpoS proteolysis is regulated by a mechanism that does not require the SprE (RssB) response regulator phosphorylation site. J Bacteriol 186: 7403-7410.

Gibbs KA, Isaac DD, Xu J, Hendrix RW, Silhavy TJ, Theriot JA (2004). Complex spatial distribution and dynamics of an abundant Escherichia coli outer membrane protein, LamB. Mol Microbiol 53: 1771-1783.

Lee YM, DiGiuseppe PA, Silhavy TJ, Hultgren SJ (2004). P pilus assembly motif necessary for activation of the CpxRA pathway by PapE in Escherichia coli. J Bacteriol 186: 4326-4337.

Hand NJ and Silhavy TJ (2004). Null mutations in a Nudix gene, ygdP, implicate an alarmone response in a novel suppression of hybrid jamming. J Bacteriol 185: 6530-6539.

Ruiz N and Silhavy TJ (2003). Constitutive activation of the Escherichia coli Pho regulon upregulates rpoS translation in an Hfq-dependent fashion. J Bacteriol 185: 5984-5992.

Bowers CW, Lau F and Silhavy TJ (2003). Secretion of LamB-LacZ by the signal recognition particle pathway of Escherichia coli. J Bacteriol 185: 5697-5705.

Shuman HA and Silhavy TJ (2003). The art and design of genetic screens: Escherichia coli. Nat Rev Genet 4: 419-431.

DiGiuseppe PA and Silhavy TJ (2003). Signal detection and target gene induction by the CpxRA two-component system. J Bacteriol 185: 2432-2440.

Duguay AR, Silhavy TJ (2002). Signal sequence mutations as tools for the characterization of LamB folding intermediates. J Bacteriol 184: 6918-6928.

Braun M and Silhavy TJ (2002). Imp/OstA is required for cell envelope biogenesis in Escherichia coli. Mol Microbiol 45: 1289-1302.

Otto K and Silhavy TJ (2002). Surface sensing and adhesion of Escherichia coli controlled by the Cpx-signaling pathway. Proc Natl Acad Sci USA 99: 2287-2292.