Tiaprofenic acid
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Tiaprofenic acid
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| Systematic (IUPAC) name | |
| 5-Benzoyl-α-methyl-2-thiopheneacetic acid | |
| Identifiers | |
| CAS number | |
| ATC code | M01 |
| PubChem | |
| Chemical data | |
| Formula | C14H12O3S |
| Mol. mass | 260.309 |
| Pharmacokinetic data | |
| Bioavailability | 90% |
| Metabolism | 10% hepatic |
| Half life | 1.5-2.5h |
| Excretion | 50-80% urine |
| Therapeutic considerations | |
| Pregnancy cat. |
C |
| Legal status |
POM |
| Routes | oral |
Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300mg twice daily. It is not recommended in children.
It is sparingly metabolised in the liver to two inactive metabolites. Most of the drug is eliminated unchanged in the urine. Renal disease impairs excretion, and it should be used with caution in renal disease.
Longterm use of tiaprofenic acid is associated with severe cystitis, roughly 100 times more commonly than other NSAIDs. It is contraindicated in patients with cystitis and urinary tract infections.
It is marketed under the trade names Surgam, Surgamyl and Tiaprofen, and in generic formulations. A sustained-release preparation is available.
[edit] References
- Crawford MLA, Waller PC, Wood SM. Severe cystitis associated with tiaprofenic acid. British Journal of Urology 1997; 79(4): 578-584.
[edit] External links
- Manufacturer Data Sheet [1]
Salicylates: Aspirin (Acetylsalicylic Acid), Diflunisal, Ethenzamide
Arylalkanoic acids: Diclofenac, Indometacin, Sulindac
2-Arylpropionic acids (profens): Carprofen, Flurbiprofen, Ibuprofen, Ketoprofen, Ketorolac, Loxoprofen, Naproxen, Tiaprofenic acid
N-Arylanthranilic acids (fenamic acids): Mefenamic acid
Pyrazolidine derivatives: Phenylbutazone
Coxibs: Celecoxib, Etoricoxib, Parecoxib, Rofecoxib, Valdecoxib
Sulphonanilides: Nimesulide
Topically used products: Diclofenac, Flurbiprofen, Ibuprofen, Indometacin, Ketoprofen, Naproxen, Piroxicam
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