Trace amine-associated receptor
From Wikipedia, the free encyclopedia
Trace amine-associated receptors, abbreviated TAAR and previously abbreviated TAR and TA, are a class of G protein-coupled receptors identified in 2001.[1]
These receptors have gained considerable interest in academic and phamaceutical industry research as putative endogenous receptors for trace amines, metabolic derivatives of classical biogenic amines.
In 2006 it was shown that TAAR1 is most probably a receptor for thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormones, while the mouse mTAAR2 - mTAAR9 receptors are most probably olfactory receptors for volatile amines.
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[edit] Mammalian TAAR complement
- Rat genome—17 genes and 2 pseudogenes
- Mouse genome—15 genes and 1 pseudogene
- Human genome—6 genes (TAAR1, TAAR2, TAAR3, TAAR5, TAAR6, TAAR8, TAAR9) and 3 pseudogenes (TAAR4P, TAAR7P)
- Chimpanzee genome—3 genes and 6 pseudogenes
[edit] See also
[edit] External links
[edit] References
- ^ B. Borowsky et al. Trace amines: identification of a family of mammalian G protein-coupled receptors, Proc. Natl. Acad. Sci. U. S. A. 98 (2001), pp. 8966–8971.
- Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci. 2005 May; 26(5): pp. 274-81.
- Nat. Med. 10(6):638-642 (2004) 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone PMID 15146179
- J. Med. Chem. 49(3):1101-1112 (2006) Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues PMID 16451074
- Nature preprint July 30 (2006) A second class of chemosensory receptors in the olfactory epithelium PMID 16878137
