Transcription coregulator
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Transcription coregulators are proteins that interact with transcription factors and regulate transcription. They can either be activators of transcription or repressors of transcription. A large number of transcription coregulators function to modify chromatin structure. One major class of transcription coregulators modify chromatin by covalent modification of histones.
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[edit] Histone acetylation
One type of covalent modification of histones is acetylation. For example, PELP-1 can act as a transcriptional corepressor for transcription factors in the nuclear receptor family such as glucocorticoid receptors.[1] Many corepressors of nuclear receptor-mediated transcription recruit histone deacetylase to promoters. Many coactivators of nuclear receptor-mediated transcription recruit histone acetyltransferase to promoters.
[edit] Nuclear receptor coactivators
- SRC-1/NCOA1 Mendelian Inheritance in Man (OMIM) 602691
- GRIP1/NCOA2 Mendelian Inheritance in Man (OMIM) 601993
- AIB1/NCOA3 Mendelian Inheritance in Man (OMIM) 601937
- PGC1 Mendelian Inheritance in Man (OMIM) 604517
- CBP (cAMP response element-binding (CREB) protein-binding protein) Mendelian Inheritance in Man (OMIM) 600140
- p300 Mendelian Inheritance in Man (OMIM) 602700
- PCAF (p300/CBP associating factor) Mendelian Inheritance in Man (OMIM) 602303[2]
[edit] Nuclear receptor corepressors
- Sin3 Mendelian Inheritance in Man (OMIM) 607776
- Rb (retinoblastoma protein) Mendelian Inheritance in Man (OMIM) 180200 (associates with histone deacetylase-1 and -2)
- CtBP 602618 Mendelian Inheritance in Man (OMIM) 607776 (associates with class II histone deacetylases)
- NcoR Mendelian Inheritance in Man (OMIM) 600849
- SMRT Mendelian Inheritance in Man (OMIM) 600848 (associates with histone deacetylase-3[1]
[edit] Dual function activator/repressors
- PELP-1 Mendelian Inheritance in Man (OMIM) 609455
- NSD1 Mendelian Inheritance in Man (OMIM) 606681
- RIP14 Mendelian Inheritance in Man (OMIM) 603826[1]
[edit] See also
[edit] References
- ^ a b c Y. B. Choi, J. K. Ko and J. Shin (2004) "The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains" in Journal of Biological Chemistry Volume 279, pages 50930-50941. Entrez PubMed 15456770
- ^ R. K. Vadlamudi, R. A. Wang, A. Mazumdar, Y. Kim, J. Shin, A. Sahin and R. Kumar (2001) "Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha" in Journal of Biological Chemistry Volume 276, pages 38272-38279. Entrez PubMed 11481323
