Travoprost
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Travoprost
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| Systematic (IUPAC) name | |
| propan-2-yl 7-[3,5-dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl) phenoxy]-but-1-enyl]-cyclopentyl]hept-5-enoate |
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| Identifiers | |
| CAS number | |
| ATC code | S01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C26H35F3O6 |
| Mol. mass | 500.548 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
C US |
| Legal status |
Schedule VI US |
| Routes | Topical (eye drops) |
Travoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes.[1] It is also known by the brand name of Travatan, manufactured by Alcon Inc. Travoprost is a synthetic prostaglandin F 2α analogue. Its chemical name is isopropyl (Z)-7- [(1 R ,2 R ,3 R ,5 S )-3,5-dihydroxy-2-[(1 E ,3 R )-3-hydroxy-4-[(α,α,α-trifluoro- m -tolyl)oxy]-1- butenyl]cyclopentyl]-5-heptenoate.[2]
Possible side effects of this medication are:
- May cause blurred vision;
- May cause eyelid redness;
- May permanently darken eyelashes;
- May cause eye discomfort;
- May eventually cause permanent darkening of the iris to brown (heterochromia);
- May cause a temporary burning sensation during use.
- May cause thickening of the eyelashes.
[edit] References
[edit] Notes
| Antiglaucoma preparations and miotics (S01E) | |
|---|---|
| Sympathomimetics | Apraclonidine, Brimonidine, Clonidine, Dipivefrine, Epinephrine |
| Parasympathomimetics | Aceclidine, Acetylcholine, Carbachol, Demecarium, Echothiophate, Fluostigmine, Neostigmine, Paraoxon, Physostigmine, Pilocarpine |
| Carbonic anhydrase inhibitors | Acetazolamide, Brinzolamide, Diclofenamide, Dorzolamide, Methazolamide |
| Beta blocking agents | Befunolol, Betaxolol, Carteolol, Levobunolol, Metipranolol, Timolol |
| Prostaglandin analogues | Bimatoprost, Latanoprost, Travoprost, Unoprostone |
| Other agents | Dapiprazole, Guanethidine |
Alprostadil - Dinoprostone - Prostacyclin
Prostaglandin analogues: Beraprost - Bimatoprost - Carboprost - Enprostil - Iloprost - Latanoprost - Misoprostol - Travoprost - Treprostinil
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