Zincke-Suhl reaction
From Wikipedia, the free encyclopedia
The Zincke-Suhl reaction is a special case of a Friedel-Crafts alkylation and was first described by Zincke and Suhl [1] [2] [3]:
The classic example of this reaction is the conversion of p-cresol to a cyclohexadienone with the aid of aluminum chloride as a catalyst and tetrachloromethane as a solvent. Melvin Newman, a scientist from the U.S. intensively studied the reaction in the 1950's and reported several improved procedures as well as mechanistic studies.
