Alclometasone
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Alclometasone
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| Systematic (IUPAC) name | |
| [7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate | |
| Identifiers | |
| CAS number | |
| ATC code | D07 S01BA10 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C28H37ClO7 |
| Mol. mass | 521.042 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | topical |
Contents |
[edit] Description
Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.
[edit] Pharmacology
Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits syntesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).
[edit] Indications
Alclometasone cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including:
- atopic dermatitis
- eczema
- psoriasis
- allergic dermatitis
- contact dermatitis
- actinic dermatitis
- kiss-type allergy
- skin itch
Alclometasone may be used on sensetive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.
[edit] Contraindications
- hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
- cutaneous tuberculosis
- chicken pox
- perioral dermatitis
- acne
- rosacea
- open wounds
- trophic ulcers
- viral infection of skin
- skin manifestations of syphilis
[edit] Side effects
Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:
- burning
- itching
- erythema
- skin reddening
- xerodermia
- skin irritation
- acne
- hypopigmentation
- prickly heat
- folliculitis
- white atrophy
- hypertrichosis
- reinfection of skin
[edit] How supplied
Alclometasone as Aclovate® is supplied in:
[edit] External links
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B)
Alclometasone, Aldosterone, Amcinonide, Beclometasone, Betamethasone, Budesonide, Ciclesonide, Clobetasol, Clobetasone, Clocortolone, Cloprednol, Cortisone, Cortivazol, Deflazacort, Deoxycorticosterone, Desonide, Desoximetasone, Desoxycortone, Dexamethasone, Diflorasone, Diflucortolone, Difluprednate, Fluclorolone, Fludrocortisone, Fludroxycortide, Flumetasone, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortin, Fluocortolone, Fluorometholone, Fluperolone, Fluprednidene, Fluticasone, Formocortal, Halcinonide, Halometasone, Hydrocortisone/cortisol, Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate, Loteprednol, Medrysone, Meprednisone, Methylprednisolone, Methylprednisolone aceponate, Mometasone furoate, Paramethasone, Prednicarbate, Prednisone, Prednisolone, Prednylidene, Rimexolone, Tixocortol, Triamcinolone, Ulobetasol
