Talk:Protein C
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The comment about activated protein c being effective in septic patients with an APACHEII score < 25 is inaccurate. The ADDRESS trial was stopped early because 28day mortality in such patients was worse (not statistically significant) in those receiving activated protein c compared to placebo. Furthermore, subgroup analyses of PROWESS and ENHANCE both support this finding. PROWESS concluded that activated protein c was effective only in those with APACHEII scores > 25, though these results are debatable. A meta-analysis of PROWESS and ADDRESS data by J. Friedrich (NEJM 2006;354(1):94-96.) suggests that activated protein c is ineffective even in those with severe sepsis (i.e. APACHEII score > 25 or multiple organ system failure). As such, many would debate that activated protein c has yet to demonstrate conclusively its worth in sepsis. —The preceding unsigned comment was added by Daleyc78 (talk • contribs) . --Daleyc78 12:59, 13 July 2006 (UTC)
