鹽酸異丙嗪
维基百科，自由的百科全书
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| N,N,alpha-trimethyl-10H-phenothiazine- 10-ethanamine (9CI) |
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| CAS number 60-87-7 |
ATC code D04AA10, R06AD02 |
| 化學式 | C17H20N2S |
| Molecular weight | 284.425 |
| Bioavailability | ? |
| Metabolism | ? |
| Elimination half-life | ? |
| Excretion | ? |
| Pregnancy category | ? |
| Legal status | ? |
| Routes of administration | ? |
鹽酸異丙嗪，又名盐酸普鲁米近(Promethazine Hydrochloride)或非那根(Phenergan)，是一種常見的止咳藥物，是一種抗組織胺藥物，能竞争性阴断组胺H1受体，对抗组胺所致之毛细血管扩张，並降低其通透性。因此，能夠平復因為氣管受刺激而引起的咳嗽。
有糖漿溶液及片狀兩種，以糖漿溶液較相見，呈鉻黃色，藥性與可待因相似，忌光，可令服用者口乾及產生睡意。這種藥水在其他國家一般都很容易可以在藥房無需處方購買。不過，由於在美國─特別是德薩斯州的休斯敦─經常被當地的年青人濫用，所以在美國需要醫生處方才可以購買。
Promethazine has strong anti-cholinergic and sedative effects. Previously in its history, promethazine has also been used as an anti-psychotic, although it is generally not administered for this purpose.
Promethazine should not be given to children under two years of age; there is potential for fatal respiratory depression in this age group.
[编辑] 參考書目
- Katzung, Bertram G. "Basic and Clinical Pharmacology", 9th ed (2004). pp. 264-265.
