Abl gene
From Wikipedia, the free encyclopedia
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v-abl Abelson murine leukemia viral oncogene homolog 1
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| Identifiers | |
| Symbol | ABL1 ABL |
| HUGO | 76 |
| Entrez | 25 |
| OMIM | 189980 |
| RefSeq | NM_007313 |
| UniProt | P00519 |
| Other data | |
| Locus | Chr. 9 q34.1 |
The abl gene is associated with chronic myelogenous leukemia. The abl gene is located on the 9th chromosome. This gene is activated by being translocated within the bcr (breakpoint cluster region) gene on chromosome 22. This new abl/bcr (chimeric) gene encodes a tyrosine kinase which allows the cells to proliferate without being regulated by cytokines. This in turn allows the cell to become cancerous.
[edit] See also
[edit] References
- Clark, Stevens. "Publications." Research Papers 1986-1989. <http://www.humonc.wisc.edu/clark/publications_abstract1x.html>
- Dunitz, Martin. "Chronic Myeloid Leukaemia" 2001. Taylor & Francis, Limited. Published online via Ebrary.com
- Scott K Shore, Ramana V Tantravahi and E Premkumar Reddy. "Transforming pathways activated by the v-Abl tyrosine kinase" 9 Dec. 2002. <http://www.nature.com/onc/journal/v21/n56/full/1206084a.html>
