Cannabidiol

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Cannabidiol
Systematic (IUPAC) name
2-((1S,6S)-3-methyl-6-(prop-1-en-2-yl) cyclohex-2-enyl)-5-pentylbenzene-1,3-diol
Identifiers
CAS number	13956-29-1
ATC code	noentry
PubChem	644019
DrugBank	none
Chemical data
Formula	C₂₁H₃₀O₂
Mol. mass	314.46
SMILES	search in eMolecules, PubChem
Physical data
Melt. point	66 °C (151 °F)
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Cannabidiol, also known as CBD, is a non-psychedelic cannabinoid found in the hemp plant Cannabis sativa.

CBD alone is not intoxicating, but it appears to affect the euphoric effect of THC (which is an isomer of cannabidiol) and add a sedative quality. It may decrease the rate of THC clearance from the body, perhaps by interfering with the metabolism of THC in the liver. Medically, it appears to relieve convulsion, inflammation, anxiety, and nausea. CBD does not appear to affect either the CB1 or CB2 receptors, possibly pointing to a still-undiscovered cannabinoid receptor in the body. ^[1] It is perceived to have more effect on the body than does THC.

Recent studies have shown cannabidiol to be as effective as atypical antipsychotics in treating schizophrenia. ^[2]

1 Medicinal use
2 References
3 See also
4 External links

[edit] Medicinal use

In April 2005, Canadian authorities approved the marketing of Sativex, a mouth spray for multiple sclerosis to alleviate pain. Sativex contains tetrahydrocannabinol together with cannabidiol. It is marketed in Canada by GW Pharmaceuticals.

[edit] References

^ Straus, Stephen E. (15 August 2000). "Immunoactive cannabinoids: Therapeutic prospects for marijuana constituents". Proc Natl Acad Sci U S A. 97 (17): 9363–9364.
^ Zuardi, A.W; J.A.S. Crippa, J.E.C. Hallak, F.A. Moreira, F.S. Guimarães (2006). "Cannabidiol as an antipsychotic drug". Brazilian Journal of Medical and Biological Research 39: 421-429. ISSN 0100-879X ISSN 0100-879X.