Talk:Codeine
From Wikipedia, the free encyclopedia
 |
Codeine is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project. | ||
|
Article Grading: The article has not been rated for quality and/or importance yet. Please rate the article and then leave comments here to explain the ratings and/or to identify the strengths and weaknesses of the article.. |
|||
[edit] Canada
"In Australia and Canada, codeine is regulated, however it is available without prescription in combination preparations from licensed pharmacists in doses up to 12.5 mg/table"
I am looking for the source of this information. I have heard many times that codeine is available without a prescription in Canada, but can not locate any references to reputable websites, such as Health Canada.
In Australia Codeine is available up to 15mg per tablet without presecription. I have updated the article.
Mystic eye 16:23, 19 December 2005 (UTC)
Also: I would like to point out that codeine is available without prescription in the UK coupled with ibuprofen in 12.8mg/tablet doses. Perhaps the article should be modified slightly to reflect this? 82.4.43.239 00:06, 9 March 2006 (UTC)
[edit] Lean
I do believe that codeine is what is used in the drink "Lean". Its an alcoholic drink most common amongst youth in Texas. Some mention should be made to that.--Jaysscholar 05:22, 23 September 2005 (UTC)
That is true to an extent. Lean is actually just the nickname of the codeine syrup that kids drink. They make mix it with drinks or coat blunts with it.
Codeine is mixed with soda such as sprite,not alcohol, to create "lean". Made popular by early pioneers of screwed music like DJ screw, Big Moe Fat Pat and LIl' Flip; they were the ones to bring codeine to the drug culture as lean.
A heroin addict may use paracetamol to ward off the effects of a withdrawal
Methadone and perhaps codeine (both opioids) may be used to ease withdrawal - but paracetamol is a different type of analgesic and I have never heard of it being used in this way.
I was addicted to Methadone for 6 months and paracetamol has no effect what so ever on withdrawls. Paracetamol contains no opiates thus has no effect on the opoid receptors craving opiates. The opiate withdrawls, being very similar to the flu (fever, cold sweets, discomfort, nausea, etc.), one would think since those are some of the uses for paracetamol that they would theoreticly work; but the causes of symptoms are manifested for completely different reasons.
CAN ANYONE FIND A SOURCE FOR THE SENTENCE ABOUT GETTING CODEINE IN NEW JERSEY WITHOUT A PRESCRIPTION? —The preceding unsigned comment was added by 63.145.150.3 (talk • contribs) .
I agree with the above concerning Paracetamol, I also was addicted to morphine, heroin and pentazocine, paracetamol is of no use for withdrawals
[edit] "it's an OPIATE not an OPIOID. Opioids are synthetic, codeine is not synthetic"
This is an editor's quotation. However according to the Wikipedia articles opioid and opiate, codeine is an opiate because it derives from opium and an opioid because it binds to the opioid receptors. Do you mean that those Wikipedia articles are incorrect? --Jclerman 20:17, 10 August 2006 (UTC)
- Codeine can be classified as either an "opioid" (a drug that binds to opioid receptors) or an "opiate" (opioid drug derived from opium). That particular editor is incorrect in saying that "opioids are synthetic" – the other articles are correct. -Techelf 10:11, 12 August 2006 (UTC)
[edit] Date of synthesization?
Does anyone know what year Codeine was first synthesized from Morphine? I was unable to find it on the DEA's Drug Information page. 19:27, August 15, 2006 BigSciZot
[edit] French Article
The article regarding codeine use in France says that codeine is not a euphoriant; it also claims 95% of the syrups use in not medicinal. Is the author credible?
[edit] UK Limits for OTC medicines
The law concerning the maximum allowable amount of codeine allowed in non-prescription medicines can be found in section 2.1 of this document on the Medicines and Healthcare products Regulatory Agency.
The strongest codeine-containing medicines available without a prescription contain 25.6mg of codeine per maximum single dose, ie Solpadeine Max (500mg Paracetamol/12.8mg Codeine per tablet, recommended dose 1-2 tablets) and Nurofen Plus (200mg Ibuprofen/12.8mg Codeine per tablet, recommended dose 1-2 tablets).80.229.137.187 20:56, 7 October 2006 (UTC)
[edit] Link on extracting codine from tablets
Is this really necessary? It seems to me that it doesn't contribute anything to the article, and it seems quite unencyclopedic 203.5.70.1 11:08, 5 November 2006 (UTC)
Is also really stupid dumb ass!!!
Well, at the least people will not damage their livers with the paracetamol
It not totally correct either. Hot water extraction would remove the paracetamol, not the codeine as is implied.
Bobby charriot 23:52, 5 January 2007 (UTC)
Is cold water extraction , not hot. And is paracetamol that damages the liver (can cause death) , not the codeine
[edit] Is Codeine/Tylenol 3 also an anti-inflamatory?
I have been perscribed Tylenol 3 for the occasional pains that occur as a result of an ongoing health problem, for use on an as-needed basis. For some time now I have not needed to take it, but I still keep it on-hand.
Last night, after nearly a month of an aching right leg, I took one tablet under the advice of my health nurse so that I would sleep better. The Tylenol 3 did indeed help the pain (as well as making me sleepy enough to spend all day in bed), and now almost 24 hours later, the pain is still very mild. Could the Tylenol 3 have had an anti-inflamatory effect and "cured" the problem with my leg? CG janitor 07:36, 21 December 2006 (UTC)
-
- Tylenol is indeed an NSAID (anti-inflammatory). I don't think codeine has much effect on that. This isn't really an appropriate conversation for a wikipedia talk page though! Go ask a doctor, or talk to your nurse some more. Gigs 00:07, 3 January 2007 (UTC)
- Actually, neither codeine nor acetaminophen is considered an anti-inflammatory. To quote the paracetamol (AKA acetaminophen) article, "Paracetamol, unlike other common analgesics such as aspirin and ibuprofen, has very little anti-inflammatory properties, and so it is not a member of the class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs)." --Galaxiaad 00:05, 4 January 2007 (UTC)
- Tylenol is indeed an NSAID (anti-inflammatory). I don't think codeine has much effect on that. This isn't really an appropriate conversation for a wikipedia talk page though! Go ask a doctor, or talk to your nurse some more. Gigs 00:07, 3 January 2007 (UTC)
[edit] Recreational use - Ilicit synthesis of morphine from codeine
The method described in the article of synthesising morphine via demethylation of codeine with pyridine is incorrect. In fact what should be used is pyridinium hydrochloride.
In the hands of an inexperienced chemist, the resulting product would likely be heavily contaminated with pyridine, resulting in a foul smell which would likely deter even a hardened addict from using it. There are much easier and cheaper ways to obtain morphine than this.
Should this be deleted from the article? The section is about recreational use, not ilicit drug synthesis.
Bobby charriot 23:46, 5 January 2007 (UTC)
[edit] Are they suggesting over 60mg of codeine at once has no use ?
there is a line there saying: "Theoretically, a dose of approximately 200 mg (oral) of codeine must be administered to give equivalent analgesia to 30 mg (oral) of morphine (Rossi, 2004). It is not used, however, in single doses of greater than 60mg (and no more than 240 mg in 24 hours) since there is a ceiling effect."
Isn.t it used in doses greater than 60mg at once?! It seems absurd. And why ? It has no extra effect ? The people using it reacreationally in average doses of 150-300 claim the contrary. Puzzled.
[edit] The section describing recreational dose is completely bogus
While I can't speak to the actual recreational and therapeutic dose ranges, the ranges listed here seem high. Consult the Physicians Desk Reference or "PDR" for the legit answer on therapeutic range. Anyone who has ever taken codiene can tell you that the therapeutic doses certainly have a recreational aspect to them, so the idea that you have to take so much more to get into the "fun" range is just logically false.
Most innaccurate, however, is the idea that the effects of the drug are limited by your liver's ability to metabolize it. The liver breaks things down. Therefore, a higher capacity for metabolization would mean less effect, not more. These is one of the most glaring errors I have ever seen on Wikipedia. This is why people without scientific backgrounds cannot be allowed to write this type of article. There are tons of "experts" out there on recreational drugs that espose nothing more than myths - whoever wrote this is one of them. Also, as for the opiate/opioid debate, both are acceptable. —The preceding unsigned comment was added by Soszai (talk • contribs) 21:50, 31 January 2007 (UTC).
Codeine containing products will typically contain 8-60mg per unit. While an opiate naive person may find a therapuetic dose (~60mg) somewhat euphoric, a person with tolerance or experience with other opiates will likely choose a dose in the range listed for recreational use. Usually codeine use is limited by the fact that at around 400mg (for most people) a ceiling effect is reached due to saturation of CYP2D6. Beyond this area there will be little (if any) therapeutic or recreational value, while the side effects will increase to an unacceptable degree. The article is accurate. My phantom limb 12:11, 26 March 2007 (UTC)
[edit] "didehydro" - unknown prefix
Please change "didehydro" in "dihydro" in the offered IUPAC name. Only "dihydro" makes sense. Thanks.
- The name refers to di-dehydro, which is something different than dihydro. The name stated in the drugbox ("(5(,6()-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol") is correct, see e.g. the drugbox entry (here). Hope this helps. --Dirk Beetstra T C 18:24, 4 March 2007 (UTC)
