Talk:Fluoxetine/Temp

Moved from main page due to copyvio. This stuff should be fine. Feel free to add to this from VERIFIED non-copyvio sources only!

“Prozac” redirects here. For other uses, see Prozac (disambiguation).



Fluoxetine/Temp
Systematic (IUPAC) name
N-methyl-3-phenyl- 3-[4-(trifluoromethyl)phenoxy]- propan-1-amine
Identifiers
CAS number	54910-89-3
ATC code	N06AB03
PubChem	3386
DrugBank	APRD00530
Chemical data
Formula	C₁₇H₁₈F₃N O
Mol. mass	309.3 (345.8 for •HCl)
Pharmacokinetic data
Bioavailability	72% peak at 6-8 hours
Protein binding	94.5%
Metabolism	Hepatic
Half life	1-3 days (acute); 4-6 days (chronic); Active metabolite Norfluoxetine 4-16 days (acute and chronic)
Excretion	Kidneys 80%, Intestines 15%
Therapeutic considerations
Licence data	EU US
Pregnancy cat.	C(US)
Legal status	℞ Prescription only
Routes	oral

Fluoxetine hydrochloride is an antidepressant drug used medically in the treatment of depression, body dysmorphic disorder, obsessive-compulsive disorder, bulimia nervosa, premenstrual dysphoric disorder, hypochondriasis and panic disorder. Fluoxetine is an atypical SSRI, in that it has been found to also increase extracellular levels of dopamine and norepinephrine in the prefrontal cortex, in addition to those of serotonin. As such, this particular SSRI may be more effective at treating depression associated with a lack of motivation or energy.[1]

Fluoxetine was derived from the antihistamine diphenhydramine, which had been found to inhibit reuptake of the neurotransmitter serotonin.[2]

[edit] See also

v • d • e Antidepressants (ATC N06A)
Monoamine oxidase inhibitors (MAOI)	Harmaline, Iproniazid, Isocarboxazid, Nialamide, Pargyline, Phenelzine, Selegiline, Toloxatone, Tranylcypromine RIMAs: Brofaromine, Moclobemide
Dopamine reuptake inhibitor (DARI)	Amineptine, Phenmetrazine, Vanoxerine
Norepinephrine-dopamine reuptake inhibitors (NDRI)	Bupropion
Norepinephrine reuptake inhibitor (NRI) or (NARI)	Atomoxetine, Maprotiline, Reboxetine, Viloxazine
Serotonin-norepinephrine reuptake inhibitor (SNRI)	Duloxetine, Milnacipran, Nefazodone , Venlafaxine
Selective serotonin reuptake inhibitor (SSRI)	Alaproclate, Citalopram, Escitalopram, Etoperidone, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine
Selective serotonin reuptake enhancer (SSRE)	Tianeptine
Noradrenergic and specific serotonergic antidepressant (NaSSA)	Mirtazapine
Tricyclic antidepressants (TCA)	Amitriptyline, Amoxapine, Butriptyline, Clomipramine, Desipramine, Dibenzepin, Dothiepin, Doxepin, Imipramine, Iprindole, Lofepramine, Melitracen, Nortriptyline, Opipramol, Protriptyline, Trimipramine
Tetracyclic antidepressants	Maprotiline, Mianserin, Nefazodone, Trazodone