Lefty (protein)
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left-right determination factor 1
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| Identifiers | |
| Symbol | LEFTY1 LEFTB |
| HUGO | 6552 |
| Entrez | 10637 |
| OMIM | 603037 |
| RefSeq | NM_020997 |
| UniProt | O75610 |
| Other data | |
| Locus | Chr. 1 q42.1 |
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left-right determination factor 2
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| Identifiers | |
| Symbol | LEFTY2 TGFB4, EBAF |
| HUGO | 3122 |
| Entrez | 7044 |
| OMIM | 601877 |
| RefSeq | NM_003240 |
| UniProt | O00292 |
| Other data | |
| Locus | Chr. 1 q42.1 |
Lefty is a class of proteins that belongs to the TGF beta superfamily of proteins. It regulates TGFβ.
It is involved in embryogenesis and left-right patterning. There are many differences between the left and right sides, including heart and lung positioning. Mutations in these genes cause incorrect positioning of these organs.
There are two human subtypes: Lefty 1 and Lefty 2. Lefty2 may play a role in endometrial bleeding.
[edit] External links
TGF beta superfamily of ligands:
Activin A and B - Anti-müllerian hormone - Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) - Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF9, GDF10, GDF11, GDF15) - Inhibin A and B - Myostatin - Nodal - TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Type II receptors:ACVR2A - ACVR2B - AMHR2 - BMPR2 - TGFBR2 - TGFBR3
Type I receptors: ACVR1A - ACVR1B - ACVR1C - ACVRL1 - BMPR1A - BMPR1B - TGFBR1
Signal transducers/SMAD: R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors: Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
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