Nodal (protein)
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| Nodal | |
|---|---|
| Genetic data | |
| Locus: | Chr. 10 q22.1 |
| Gene code: | HUGO code:NODAL |
| Protein Structure/Function | |
| Protein type: | cytokine |
| Functions: | cell differentiation |
| Domains: | TGFβ domain |
| Other | |
| Taxa expressing: | Homo sapiens; homologs: many metazoan phyla |
| Cell types: | many |
| Subcellular localization: | Extracellular |
| Medical/Biotechnological data | |
| Diseases: | Situs Ambiguus Mendelian Inheritance in Man (OMIM) 601265 |
| Database Links | |
| Entrez: | 4838 |
| OMIM: | 601265 |
| RefSeq: | NM_018055 |
| UniProt: | Q96S42 |
Nodal is a polypeptide member of the transforming growth factor beta superfamily of polypeptides. Like many other members of this superfamily, it is involved in cell differentiation. Nodal plays an essential role in mesoderm formation and axis specification. Nodal null mice die shortly after gastrulation[1].
[edit] References
- ^ Reissmann E,; Jornvall H, Blokzijl A, Andersson O, Chang C, Minchiotti G, Persico MG, Ibanez CF, Brivanlou AH. (Aug 2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development". Genes Dev. 15 (15). Entrez PubMed 11485994. Retrieved on 2006-07-05.
TGF beta superfamily of ligands:
Activin A and B - Anti-müllerian hormone - Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) - Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF9, GDF10, GDF11, GDF15) - Inhibin A and B - Myostatin - Nodal - TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Type II receptors:ACVR2A - ACVR2B - AMHR2 - BMPR2 - TGFBR2 - TGFBR3
Type I receptors: ACVR1A - ACVR1B - ACVR1C - ACVRL1 - BMPR1A - BMPR1B - TGFBR1
Signal transducers/SMAD: R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors: Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
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