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Niaprazine (Nopron) is a piperazine derivative drug which acts as a sedating antihistamine. It was invented in the 1970s [1], and is used in France and other european countries. It is mainly prescribed for its relatively strong sedative effects rather than as an antihistamine, and is used mainly for treating autism [2] and insomnia [3] in children and adolescents.
Niaprazine half-life is 4.53 +- 0.86 hours.
Common side effects are: sedation during the day (above all during the first few days), vertigo
N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide
CAS# 27367-90-4; 34426-53-4
[edit] References
- ^ Duchene-Marullaz P, Rispat G, Perriere JP, Hache J, Labrid C. Some pharmacodynamical properties of niaprazine, a new antihistaminic agent. (French) Therapie. 1971 Nov-Dec;26(6):1203-9.
- ^ Rossi PG, Posar A, Parmeggiani A, Pipitone E, D'Agata M. Niaprazine in the treatment of autistic disorder. Journal of Child Neurology. 1999 Aug;14(8):547-50.
- ^ Younus M, Labellarte MJ. Insomnia in children: when are hypnotics indicated? Paediatric Drugs. 2002;4(6):391-403.
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Antihistamines (primarily R06) |
| Aminoalkyl ethers |
Bromazine, Carbinoxamine, Clemastine, Chlorphenoxamine, Diphenylpyraline, Diphenhydramine, Doxylamine |
| Substituted alkylamines |
Brompheniramine, Chlorphenamine, Dexbrompheniramine, Dexchlorpheniramine, Dimetindene, Pheniramine, Talastine |
| Substituted ethylene diamines |
Chloropyramine, Histapyrrodine, Mepyramine, Methapyrilene, Pyribenzamine |
| Phenothiazine derivatives |
Alimemazine, Hydroxyethylpromethazine, Isothipendyl, Mequitazine, Methdilazine, Oxomemazine, Promethazine |
| Piperazine derivatives |
Buclizine, Cetirizine, Chlorcyclizine, Cinnarizine, Cyclizine, Hydroxyzine, Levocetirizine, Meclozine, Niaprazine, Oxatomide |
| Others for systemic use |
Acrivastine, Antazoline, Astemizole, Azatadine, Azelastine, Bamipine, Cyproheptadine, Deptropine, Desloratadine, Ebastine, Epinastine, Ketotifen, Loratadine, Mebhydrolin, Mizolastine, Phenindamine, Pimethixene, Pyrrobutamine, Rupatadine, Terfenadine, Triprolidine |
| For topical use |
Bamipine, Chloropyramine, Chlorphenoxamine, Clemastine, Dimetindene, Diphenhydramine, Isothipendyl, Mepyramine, Promethazine, Thenalidine |
| Antiallergic agents excluding corticosteroids |
Antazoline, Azelastine, Fexofenadine |
| Other antiallergics |
Emedastine, Epinastine, Ketotifen, Olopatadine |
