F-box protein
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F-box proteins are proteins containing at least one F-box motif, a protein structural motif of about 50 amino acids that mediates protein-protein interactions. The first identified F-box protein is one of three components of the SCF complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome. F-box motifs commonly exist in proteins in concert with other protein-protein interaction motifs such as leucine-rich repeats and WD repeats.[1]
F-box proteins have also been associated with cellular functions such as signal transduction and regulation of the cell cycle.[2] In plants, many F-box proteins are represented in gene networks broadly regulated by microRNA-mediated gene silencing via RNA interference.[3]
[edit] References
- ^ Kipreos ET, Pagano M. (2000). The F-box protein family. Genome Biol 1(5):REVIEWS3002. PMID 11178263
- ^ Craig KL, Tyers M. (1999). The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction. Prog Biophys Mol Biol 72(3):299-328. PMID 10581972
- ^ Jones-Rhoades M, Bartel D, Bartel B. "MicroRNAS and their regulatory roles in plants". Annu Rev Plant Biol 57: 19-53. PMID 16669754
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