Famciclovir
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Famciclovir
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| Systematic (IUPAC) name | |
| [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)-butyl] acetate | |
| Identifiers | |
| CAS number | |
| ATC code | J05 S01AD07 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C14H19N5O4 |
| Mol. mass | 321.332 g/mol |
| Physical data | |
| Melt. point | 103 °C (217 °F) |
| Pharmacokinetic data | |
| Bioavailability | 75–77% |
| Protein binding | 20-25% |
| Metabolism | Hepatic, circulation, intestinal wall (to penciclovir) |
| Half life | 2–2.3 hours |
| Excretion | Renal, faecal |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status |
S4 (Au), POM (UK), ℞-only (U.S.) |
| Routes | Oral |
Famciclovir (INN) (IPA: [pɛnˈsaɪklovir]) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Novartis).
In Korean it is sold under the brand name 팜시바 with the generic name of 팜시클바.
Side effects: mild to extreme stomach upset, headaches, mild fever.
[edit] See also
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| Anti-herpesvirus | Aciclovir, Cidofovir, Docosanol, Famciclovir, Fomivirsen, Foscarnet, Ganciclovir, Idoxuridine, Penciclovir, Trifluridine, Tromantadine, Valaciclovir, Valganciclovir, Vidarabine |
| Anti-influenza agents | Amantadine, Arbidol, Oseltamivir, Peramivir, Rimantadine, Zanamivir |
| Antiretrovirals: NRTIs | Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, Zalcitabine, Zidovudine |
| Antiretrovirals: NtRTIs | Tenofovir |
| Antiretrovirals: NNRTIs | Efavirenz, Delavirdine, Nevirapine, Loviride |
| Antiretrovirals: PIs | Amprenavir, Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir |
| Antiretrovirals: Fusion inhibitors | Enfuvirtide |
| Other antiviral agents | Adefovir, Fomivirsen, Imiquimod, Inosine, Interferon, Podophyllotoxin, Ribavirin, Viramidine |
