Methysergide

From Wikipedia, the free encyclopedia


Methysergide
Systematic (IUPAC) name
1-Methyl-d-lysergic acid-(1-hydroxybut-2-yl)amide
Identifiers
CAS number	361-37-5
ATC code	N02CA04
PubChem	9681
DrugBank	APRD00463
Chemical data
Formula	C₂₁H₂₇N₃O₂
Mol. mass	353.458 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Methysergide (UML-491) is a prescription drug used for prophylaxis of migraine headaches and is sold under the brand names Sansert^® and Deseril^® in 2mg dosages. Methysergide was approved by the FDA in 1962. Its molecular structure is closely related to that of LSD.

Methysergide is one of the most effective medications for the prevention of migraine, but not for the treatment of an acute attack. It has a known side effect, retroperitoneal fibrosis^[1], which is severe, although uncommon. Novartis withdrew it from the U.S. market after taking over Sandoz, but currently lists it as a product.

Like LSD, methysergide also produces psychedelic and hallucinogenic effects above a dosage of about 4mg.^[2] Full effects are felt with dosages of 8-20mg.^{[citation needed]}

[edit] See also

Triptan

[edit] References

^ emedicine.com (2002)
^ L. Bender (1970): "Children's Reactions to Psychotomimetic Drugs", Psychotomimetic Drugs, pp. 265-273

[edit] External links

Novartis Sansert site.
Novartis Sansert product description.
Migraines.org More detailed information on methysergide.
neurologychannel.com, general information on migraines.

v • d • e Ergolines
Lysergic acid derivatives	Bromocriptine, Cabergoline, Ergine,Ergonovine, Ergotamine, Lysergic acid, Lysergol, LSD, D-Lysergic acid hydroxyethylamide, Lisuride, Methergine, Methysergide, Pergolide
Hallucinogenic lysergamides	AL-LAD, ALD-52, BU-LAD, CYP-LAD, DAL, DAM-57, Ergonovine, ETH-LAD, LAE-32, LSD, LPD-824, LSM-775, Methylergonovine, MLD-41, PARGY-LAD, PRO-LAD
Other ergolines	Ergoline
Natural sources	Argyreia nervosa, Claviceps spp., Ipomoea tricolor, Ipomoea violacea, Rivea corymbosa