Myeloproliferative disease
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| ICD-10 | D47.1 |
|---|---|
| ICD-9 | 205.1, 238.4, 289.89, 289.9 |
| ICD-O: | 9950/0-9964/3 |
The myeloproliferative diseases ("MPD"s) are a group of diseases of the bone marrow in which excess cells are produced. They are related to, and may evolve into, myelodysplastic syndrome and acute myeloid leukemia, although the myeloproliferative diseases on the whole have a much better prognosis than these conditions. The concept of myeloproliferative disease was first proposed in 1951 by the eminent hematologist William Dameshek.[1]
Although not a malignant neoplasm, MPDs are classified within the hematological neoplasms.
The myeloproliferative diseases are (with ICD-O codes provided):
- (9863/3) Chronic myelogenous leukemia (CML)
- (9950/3) Polycythemia vera (PCV)
- (9962/3) Essential thrombocytosis (ET)
- (9932/3, 9961/1) Myelofibrosis (increased connective tissue with decreased room for production of normal blood cells).
All MPDs arise from precursors of the "myeloid" lineage in the bone marrow. The lymphoid lineage may produce similar diseases, the lymphoproliferative disorders (acute lymphoblastic leukemia, lymphomas, chronic lymphocytic leukemia and multiple myeloma).
[edit] References
- ^ DAMESHEK W (1951). "Some speculations on the myeloproliferative syndromes.". Blood 6 (4): 372-5. PMID 14820991.
[edit] External links
- Myeloproliferative Disease Support List
- Association of Cancer Online Resource (ACOR) Myeloproliferative Disorders page
- MeSH Myeloproliferative+Disorders
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Hematological malignancy and White blood cells
Lymphoid: Lymphocytic leukemia (ALL, CLL, HCL) • Lymphoma (Hodgkin's disease, NHL) • LPD • Myeloma (Multiple myeloma, Extramedullary plasmacytoma)
Myeloid: Myelogenous leukemia (AML, CML) • MPD (Essential thrombocytosis, Polycythemia) • MDS • Myelofibrosis • Neutropenia
Red blood cells
Anemia • Hemochromatosis • Sickle-cell disease • Thalassemia • Hemolysis • Aplastic anemia • G6PD Deficiency • Hereditary spherocytosis • Hereditary elliptocytosis • Other hemoglobinopathies
Coagulation and Platelets
Thrombosis • Deep vein thrombosis • Pulmonary embolism • Hemophilia • ITP • TTP • DIC
