Nedocromil
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Nedocromil
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| Systematic (IUPAC) name | |
| 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro- 4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid |
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| Identifiers | |
| CAS number | |
| ATC code | R01 R03BC03, S01GX04 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C19H17NO7 |
| Mol. mass | 371.341 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 89% |
| Metabolism | not metabolized |
| Half life | ~3.3 hours |
| Excretion | excreted unchanged |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Inhalation and eye drops |
Nedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade®.
Nedocromil is classified as a cromone. Nedocromil acts as a mast cell stabilizer, reducing the release of inflammatory mediators such as histamine from mast cells.
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| Medications commonly used in asthma and COPD (primarily R03) | |
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| Anticholinergics | Ipratropium, Tiotropium |
| Short acting β2-agonists | Salbutamol, Terbutaline |
| Long acting β2-agonists (LABA) | Bambuterol, Clenbuterol, Fenoterol, Formoterol, Salmeterol |
| Corticosteroids | Beclometasone, Budesonide, Ciclesonide, Fluticasone |
| Leukotriene antagonists | Montelukast, Pranlukast, Zafirlukast |
| Xanthines | Aminophylline, Theobromine, Theophylline |
| Mast cell stabilizers | Cromoglicate, Nedocromil |
| Combination products | Budesonide/formoterol, Fluticasone/salmeterol, Ipratropium/salbutamol |
