Osteocalcin
From Wikipedia, the free encyclopedia
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bone gamma-carboxyglutamate (gla) protein (osteocalcin)
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| Identifiers | |
| Symbol | BGLAP |
| HUGO | 1043 |
| Entrez | 632 |
| OMIM | 112260 |
| RefSeq | NM_199173 |
| UniProt | P02818 |
| Other data | |
| Locus | Chr. 1 q25-q31 |
Osteocalcin is a noncollagenous protein found in bone and dentin. It is secreted by osteoblasts and thought to play a role in mineralization and calcium ion homeostasis. It has been stipulated that osteocalcin may also function as a negative regulator of bone formation, although its exact role is unknown.
[edit] Use as a biochemical marker for bone formation
As osteocalcin is manufactured by osteoblasts, it is often used as a biochemical marker, or biomarker, for the bone formation process. It has been routinely observed that higher serum-osteocalcin levels are relatively well correlated with increases in bone mineral density (BMD) during treatment with anabolic bone formation drugs for osteoporosis, such as Forteo. In many studies, Osteocalcin is used as a preliminary biomarker on the effectiveness of a given drug on bone formation.
[edit] External links
Annexin (A1, A2, A5) - Vitamin D-dependent calcium-binding protein/Calbindin - Calexcitin - Calsequestrin - Osteocalcin - Osteonectin - S-100 - Synaptotagmin - Troponin C
Intracellular calcium-sensing proteins: Calmodulin - Calnexin - Calreticulin - Gelsolin - neuronal (Hippocalcin, Neurocalcin, Recoverin)
