Primase
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DNA primase is a form of RNA polymerase and a product of the dnaG gene. In bacteria, primase binds to the DNA helicase forming a complex called the primosome. Primase is activated by DNA helicase where it then synthesizes a short RNA primer approximately 11 ±1 nucleotides long, to which new nucleotides can be added by DNA polymerase. Primase is of key importance in DNA replication because no known DNA polymerases can initiate the synthesis of a DNA strand without initial RNA primers.
A primer is a short RNA segment that is complementary to a DNA segment, and is necessary to begin DNA replication.
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Origin of replication/Ori/Replicon - DNA clamp - Okazaki fragment - Replication fork (Lagging and leading strands) - Single-strand binding protein - Primer - Processivity - Klenow fragment
Pre-replication complex: Helicase (dnaA, dnaB, T7) - Primase (dnaG) - DNA polymerase III holoenzyme (dnaQ)
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