SERCA
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SERCA stands for Sarco/Endoplasmic Reticulum Ca2+-ATPase
SERCA resides in the sarcoplasmic reticulum (SR) within muscle cells. It is a Ca2+ ATPase which transfers Ca2+ from the cytosol of the cell to the lumen of the SR at the expense of ATP hydrolysis.
There are 3 major isoforms, SERCA1-3, which are expressed at various levels in different muscle types.
The rate at which SERCA moves Ca2+ across the SR membrane can be controlled by phospholamban (PLB/PLN) under ß-adrenergic stimulation. When PLB is associated with SERCA, the rate of Ca2+ movement is reduced, upon dissociation of PLB Ca2+ movement increases.
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Symporter: Na+/K+/2Cl- - Na/Pi3 - Na+/Cl- - Na/glucose
Antiporter (exchanger): Na+/H+ - Na+/Ca2+ - Cl-/HCO3- (Band 3)
ATPase: H+ (F-type) - H+ (V-type) - H+/K+ - Na+/K+ - Ca+ (SERCA, Plasma membrane)
