Talk:Suicide inhibition
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What is a beta-gamma unsaturated carbon? How can a carbon atom be beta-gamma unsaturated? I also believe that there are other reactive intermediates formed, besides the three listed. For instance, Diisopropylfluorophosphate does not form any of the intermediates listed.
[edit] "normal"
"is a form of irreversible enzyme inhibition that occurs when an enzyme binds a substrate analogue and forms a complex with it during the "normal" catalysis reaction." This is very unclear? I am in my second year of chemistry and the explanation offered on the mechanism behind suiced inhibition is at best unclear. I understand what is meant but i think it needs a major rewrite: Suicide inhibition is the irrevesible inhibition of an enzyme by a substrate. It does this by undergoing some basic steps of the intented enzymatic reaction but instead of being releassed from the active site, the inhibitor has become a highly reactive complex which binds very strongly (and therefore irrevesibly) to the active site, thus achiving the permanent inhibition. Its called suicide inhibition because the inhibitor (and the enzyme) is destroyed. Is this any better? I am new to wikipedia and dont know how to go about editing... —The preceding unsigned comment was added by Leonidaslundell (talk • contribs).
I'm not sure it has to bind to the active site. I'll check on that. David D. (Talk) 15:03, 15 September 2006 (UTC)
